Prolotherapy is an effective treatment for muscular and skeletal injuries and the accompanying state of pain. Clinical grade dextrose or mannitol is injected just below the skin to facilitate the healing of the injured nerves.
It was discovered that the dextrose in prolotherapy promotes healing of connective tissues like ligaments and tendons but also the surrounding nerves.
Once these nerves function normally, healing of deeper tissues would happen and thus relieve the pain.
When a tissue is injured, it releases substances that cause inflammation. Dextrose, the key substances used in Prolotherapy, bind to and inhibit the nerve receptors, and prevent further production of inflammatory fluids. That restores the normal functioning of the nerves.